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1996-02-27
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Document 0217
DOCN M9630217
TI [Characteristics of chronic delta hepatitis in patients wih HIV
infection]
DT 9603
AU De Pouplana M; Soriano V; Garcia-Samaniego J; Enriquez A; Munoz F;
Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas. Centro de
Investigaciones; Clinicas. Instituto de Salud Carlos III, Madrid.
SO Rev Esp Enferm Dig. 1995 Oct;87(10):721-4. Unique Identifier : AIDSLINE
MED/96103278
AB BACKGROUND: Hepatitis Delta virus (HDV) induces severe liver disease in
HBsAg carriers. In regions such as Spain, drug addicts make-up a large
part of the HIV-positive population and they are at risk of HDV
infection. Natural history of chronic hepatitis D is not well known in
HIV-infected patients. METHODS: We reviewed the clinical charts of 37
patients attending our institution from 1989 to 1993, fulfilling the
criteria for chronic hepatitis D. We compared all clinical,
epidemiological, serological and histological findings between both
HIV-positive and HIV-negative patients. RESULTS: All the following
parameters showed significant statistical differences between the both
groups: mean ALT levels (175 vs 79 respectively, p < 0.05), previous
episodes of hepatic decompensation (37% vs 10%, p < 0.01), the
circulating Delta antigen (26% vs 10%, p < 0.05), the presence of HBeAg
in serum (41% vs 0%, p < 0.01) and the HCV coinfection (85% vs 20%, p <
0.01). Histological findings were not significantly different comparing
both groups, as chronic active hepatitis with cirrhosis was the most
common diagnosis. CONCLUSION: Chronic hepatitis D may present a more
severe course in HIV-infected patients. The higher replication of HDV
and the presence of HCV coinfection could explain this worst outcome.
DE Adult Chronic Disease Comparative Study Delta
Infection/DIAGNOSIS/*ETIOLOGY English Abstract Female Hepatitis
C/COMPLICATIONS Human HIV Infections/*COMPLICATIONS HIV
Seronegativity HIV Seropositivity/COMPLICATIONS Male Middle Age Risk
Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).